When it comes to preserving testicular function, testicular size and fertility during a cycle (or during TRT), HCG is always the first peptide hormone to be suggested.
Its usefulness is unquestionable because the vast majority of men who implement it are able to prevent/reverse testicular atrophy and a reduction in spermatogenesis, but there are situations in which HCG is simply not strong enough.
Some men are unable to restore their fertility after blasting and cruising on all kinds of gear without using HCG for years or even decades on end. That is where HMG comes into play.
THE DIFFERENCE BETWEEN HCG AND HMG
HCG (Human Chorionic Gonadotropin; Pregnyl) is a peptide hormone found in the urine of pregnant women (although men also produce it in miniscule amounts in the pituitary gland) which acts as an analogue of LH (Luteinizing Hormone).
LH is the hormone that is responsible for stimulating Testosterone production, which at the same time supports sperm production. Therefore, by using HCG, men are able to replace their natural LH (which is shut down by AAS) and get their testicles to start working again.
HMG (Human Menopausal Gonadotropin) is a mixture of gonadotropins (peptide hormones) found in the urine of postmenopausal women. Unlike HCG, which simply acts as an analogue of LH, HMG contains both LH and FSH.
Even though LH is enough to stimulate sperm production through an increase in Testosterone production, FSH (Follicle-Stimulating Hormone) is the true promoter of spermatogenesis and fertility. Therefore, HMG is much more effective at restoring fertility in seriously compromised men than HCG is.
WHICH SHOULD YOU PICK? HOW TO USE THEM?
You should aim to never have to use HMG. How? By using HCG as a preventive measure with your cycles / cruising to ensure that you never find yourself so heavily suppressed and sterilized that you need HMG.
If you do not care about fertility, you can ignore this article. However, if you are on TRT or you are blasting and cruising and you want to remain fertile to hopefully have kids one day, you should be using around 1000iu of HCG every week (500iu every 3 days will do). Doing this will ensure that your testicles always remain active, and it will preserve your fertility while making it easier for you to execute a successful PCT if you wish to come off completely.
The only thing worth noting is that using HCG with TRT and/or a blast will increase your estradiol levels, so keep that in mind and decrease your Testosterone dose or use an AI (if strictly necessary) to keep estradiol under control.
If you have been on TRT or blasting & cruising for years and you have not been using HCG, chances are your fertility will be seriously low. Get bloodwork done as well as a sperm test to check whether you are fertile or not.
If you are not and you want to reactivate your testicles to become fertile again, you can try using HCG at 500iu every other day along with Enclomiphene at 12.5mg/day for 6 weeks. By the end of it, get another sperm test to see if it worked or not.
If it did not work, try doing the same protocol but use 50iu of HMG twice a week with the same amount of Enclomiphene instead of using the HCG.
Best of luck restoring your fertility!