Serrapeptase 101

Serrapeptase 101

Serrapeptase, also known as serratiopeptidase, is a proteolytic enzyme derived from the Serratia bacteria found in silkworms. It’s gained attention as a natural supplement with anti-inflammatory, pain-reducing, and cardiovascular benefits, making it a popular addition to many health regimens.

Originally used in Japan and Europe for treating inflammation and pain, serrapeptase is now recognized for its potential benefits in promoting cardiovascular health and assisting bodybuilders, especially those using performance-enhancing drugs (PEDs).

Cardiovascular health benefits

Serrapeptase has gained popularity for its unique ability to break down “non-living” proteins in the body, such as scar tissue and arterial plaque. By helping to clots and material from arteries, serrapeptase promotes better blood flow, reduces the risk of blood clots, and supports overall cardiovascular health. Research suggests it can reduce the thickness of arterial walls, which helps prevent atherosclerosis (plaque buildup in the arteries), lowering the risk of heart attack and stroke.

Additionally, it has anti-inflammatory properties, which benefit cardiovascular health by reducing inflammation that contributes to arterial plaque formation and cardiovascular disease.

Benefits for bodybuilders using PEDs

For bodybuilders using PEDs, serrapeptase offers benefits that can counteract some of the negative side effects associated with these substances. PEDs can lead to cardiovascular strain, as well as inflammation in muscles and joints from the increased stress of high-intensity workouts. Serrapeptase’s ability to reduce inflammation and dissolve scar tissue can relieve strain on the heart, while also aiding muscle and joint recovery.

Furthermore, PED use can increase blood viscosity, putting users at a higher risk of clots. Serrapeptase may help mitigate this risk by reducing clot formation, thus supporting healthier blood flow and reducing cardiovascular risks.

How to dose serrapeptase properly

For general health, the recommended dosage of serrapeptase typically ranges from 20,000 to 120,000 SU (serrapeptase units) per day, taken on an empty stomach for optimal absorption. For cardiovascular benefits or inflammation reduction, dosages of 40,000 to 120,000 SU daily are common, with some individuals taking up to 240,000 SU per day, split into two doses. Since serrapeptase is an enzyme, its effects are cumulative, so consistency is key.


In conclusion, serrapeptase stands out as a valuable supplement for cardiovascular support and inflammation reduction, especially for enhanced bodybuilders using PEDs. By breaking down non-living proteins, reducing arterial plaque, and supporting healthier blood flow, it provides a natural way to mitigate some of the cardiovascular risks associated with intense training and PED use. With proper dosing and consistent use, serrapeptase can be an effective addition to a wellness regimen aimed at optimizing heart health, reducing inflammation, and enhancing recovery.

William Davis

William has been studying and experimenting with bodybuilding pharmacology for over 6 years. After being an independent researcher for all these years, he has decided to share his knowledge with the bodybuilding community through his science-based articles. His approach to enhanced bodybuilding can be summed up in the saying “less is more”, as he believes that prioritizing harm mitigation and looking for ways to maximize the positives is the key to longevity in bodybuilding.

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