Post-finasteride syndrome myth or reality

Post-finasteride syndrome: myth or reality?

Post-Finasteride Syndrome (PFS) is a term used to describe a set of persistent side effects that some individuals experience after discontinuing the use of Finasteride. Finasteride is a prescription drug used to treat hair loss and an enlarged prostate in men. It works by inhibiting the conversion of Testosterone to Dihydrotestosterone (DHT), the main hormone responsible for hair loss and prostate enlargement.

While Finasteride is generally considered safe, some individuals who take the medication experience persistent side effects, even after stopping the drug. These side effects can include sexual dysfunction, cognitive impairment, depression, anxiety, and physical symptoms such as muscle weakness and joint pain.

The severity and duration of these side effects can vary widely among individuals, with some users experiencing mild symptoms that resolve quickly, while others experience more severe and persistent symptoms that can last for years.

Causes of PFS

The exact cause of PFS is not fully understood, and there is ongoing debate among researchers and medical professionals about its prevalence, mechanisms, and treatment options.

Some experts believe that PFS is caused by the long-term inhibition of DHT and other hormones, which can disrupt the normal functioning of the endocrine system and lead to a range of physical and psychological symptoms.

Others suggest that PFS may be caused by epigenetic changes induced by the medication, but there is no clear scientific evidence to support that theory.

Common symptoms of PFS

Sexual dysfunction is one of the most common and distressing symptoms of PFS, with many individuals reporting a loss of libido, erectile dysfunction, and decreased semen volume. In some cases, these symptoms can persist for up to 4 years after stopping the medication, leading to long-term sexual dysfunction and relationship problems.

Cognitive impairment is another common symptom of PFS, with many individuals reporting difficulty concentrating, memory loss, and brain fog. This can have a significant impact on work and social functioning, and may also contribute to depression and anxiety.

Physical symptoms of PFS can also be debilitating, with many individuals reporting muscle weakness, joint pain, and fatigue. These symptoms can make it difficult to engage in physical activity or work and may also contribute to depression and anxiety.

Needless to say, the combination of all these factors causes people who suffer from PFS to become less confident, motivated and ambitious in life.

Treatment options

Currently, there is no consensus on the best treatment options for PFS, and management of the condition is largely supportive. Some individuals may benefit from hormone replacement therapy or other medications to address specific symptoms, but in most cases the condition eventually goes away on its own (it can take anywhere from a few months to 4+ years in the most extreme cases).

Fortunately, only about 1.2% of men who use Finasteride develop long-lasting side-effects, so PFS is a rare condition that the vast majority of Finasteride users will never face.

The alternative

If you are currently using Finasteride and you have NOT experienced any of these symptoms, chances are you are not prone to PFS and should not worry about it. PFS symptoms do not just appear AFTER Finasteride treatment, but during it as well.

If you are facing hair loss and you are considering Finasteride, I suggest you look into RU-58441. This research chemical is applied to the scalp, where it blocks androgen receptors locally to prevent hair loss WITHOUT causing a systemic drop in DHT levels and the side-effects that come from that.

If you are considering Finasteride use for the treatment of prostate enlargement, I suggest you use Tadalafil instead. Studies show that it prevents prostate enlargement while improving cardiovascular health and sexual function, all without affecting DHT levels negatively.


Even though it is unlikely that you will face PFS if you do use Finasteride, the potential side-effects are so scary that I think it is worth trying safer alternatives before eventually resorting to it. Is a full head of hair worth a miserable life?


William Davis

William has been studying and experimenting with bodybuilding pharmacology for over 6 years. After being an independent researcher for all these years, he has decided to share his knowledge with the bodybuilding community through his science-based articles. His approach to enhanced bodybuilding can be summed up in the saying “less is more”, as he believes that prioritizing harm mitigation and looking for ways to maximize the positives is the key to longevity in bodybuilding.

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