Sobetirome T3 without the side-effects

Sobetirome: T3 without the side-effects?

Sobetirome (also known as GC-1) is a Thyroid Receptor Beta-Specific Agonist drug that was developed as a potential alternative to T3 and T4 for the treatment of hypothyroidism.

As you know, the thyroid hormones T3 and T4 regulate metabolism and other important physiological processes within the body, so being thyroid deficient is not only incredibly unhealthy, but it also leads to weight gain and makes it very hard for one to lose fat.

Hypothyroidism is generally treated with exogenous T3 and T4. Taking T3 and/or T4 to treat hypothyroidism is like taking Testosterone to treat hypogonadism (low testosterone).

The problem with these medications is that they target both Thyroid Receptors Alpha and Thyroid Receptors Beta. The former are linked to increases in heart rate (which are dangerous), and the latter are linked to increased fat loss (which is what we want).

Sobetirome is a thyroid mimetic that was developed by modifying the T3 molecule. Unlike T3, Sobetirome has very low affinity for Thyroid Receptors Alpha, and mainly targets Thyroid Receptors Beta, meaning that it has the fat loss benefits of T3 and T4 without sharing their negative cardiovascular side-effects.

Benefits of Sobetirome

Sobetirome is incredibly effective at burning fat by turning white fat (which is the fat we want to burn) into brown fat (which increases body temperature and contributes to losing weight).

Sobetirome also lowers LDL cholesterol. It may have other benefits, but the scientific and anecdotal data on this drug is very limited so we don’t know exactly what they are yet.

Side-effects of Sobetirome

Based on the information we have about it, Sobetirome appears to be a very safe drug that can offer the benefits of thyroid hormone therapy without the dangerous cardiovascular side-effects.

However, Sobetirome will most definitely increase body temperature and sweating. This side-effect is not dangerous per se, but it can be incredibly annoying in warm climates.

How to use it

There is almost no anecdotal information about Sobetirome on the internet, so the PED community has not come to a consensus on how to dose it properly yet.

I would personally recommend starting at 50mcg a day (orally), and slowly working up to 100mcg a day and beyond IF well tolerated.

I would keep cycle length at 8 weeks max. We just don’t know what can happen to people who take it for extended periods of time.

In conclusion, Sobetirome is a promising fat-burning compound that could easily replace T3 as one of the most popular cutting agents in the future.


William Davis

William has been studying and experimenting with bodybuilding pharmacology for over 6 years. After being an independent researcher for all these years, he has decided to share his knowledge with the bodybuilding community through his science-based articles. His approach to enhanced bodybuilding can be summed up in the saying “less is more”, as he believes that prioritizing harm mitigation and looking for ways to maximize the positives is the key to longevity in bodybuilding.

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