5-A-1MQ The fat-burner you’ve never heard of

5-A-1MQ: The fat-burner you’ve never heard of

5-Amino-1MQ is a short-chain peptide that has shown promising results in the treatment of obesity. It is slowly growing in popularity as an excellent oral fat-burner that can reduce body fat significantly without causing serious side-effects.

What does 5-AMINO-1MQ do?

5-Amino-1MQ is a membrane-permeable peptide that works by inhibiting NNMT (Nicotinamide N-methyltransferase) and increasing NAD+. NNMT is an enzyme found in fat tissue that stops fat cell metabolism, making it harder for fat cells to be “burnt”. I am obviously simplifying this explanation for the sake of simplicity but think of NNMT as the natural mechanism through which the body ensures that body fat percentages don’t drop too low (since that would actually be bad from an evolutionary perspective).

NAD+, which 5-Amino-1MQ increases, has been linked to longevity, optimal metabolic function and SIRT-1 activation. SIRT-1 is known to decrease the occurrence of cancer, heart disease, diabetes and even kidney disease.

The benefits of 5-AMINO-1MQ

Here’s what you can expect from this peptide according to studies:

  • 5-A-1MQ will burn fat by inhibiting NNMT, which facilitates the use of stored fat for energy.
  • 5-A-1MQ will reduce inflammation.
  • 5-A-1MQ will reduce cholesterol levels.
  • 5-A-1MQ will increase NAD+ levels, which are linked to longevity and a lower risk of cancer, cardiovascular disease, kidney disease, type 2 diabetes…
  • 5-A-1MQ is orally bioavailable, so there’s no need to inject it.
  • 5-A-1MQ may help build muscle, but data on this is very unclear.

The side-effects of 5-AMINO-1MQ

No side-effects have been observed in studies or anecdotally, but given the general lack of data on 5-Amino-1MQ, it is possible for it to have long-term side-effects that we are not aware of.

Anecdotal reports on 5-AMINO-1MQ

Not many people have used this peptide because it can be hard to find and expensive, but nearly every user I’ve talked to or read about who has used it reports incredible results.

It is still necessary to be on a caloric deficit (preferably through both diet and cardio) to lose fat on 5-A-1MQ, but people report a much faster rate of fat loss without the jitters, anxiety, high blood pressure, tachycardia and high body temperature that traditional fat-burners are known for.

5-AMINO-1MQ protocol for bodybuilders

Anecdotally, 5-A-1MQ provides the best results when dosed at 100 to 150mg a day.

Given how “safe” it is on paper, it can be used for 2 to 3 months so it can be part of an entire cutting cycle.

The half-life of 5-A-1MQ is unknown, so taking it 2 or 3 times a day is preferable (morning, noon, evening or morning & evening).


In conclusion, 5-Amino-1MQ appears to be a very safe and highly effective fat-burning agent that can be used on its own or as part of a more intricate cutting cycle, but more scientific and anecdotal data about it is needed to know what its potential long-term effects are.


William Davis

William has been studying and experimenting with bodybuilding pharmacology for over 6 years. After being an independent researcher for all these years, he has decided to share his knowledge with the bodybuilding community through his science-based articles. His approach to enhanced bodybuilding can be summed up in the saying “less is more”, as he believes that prioritizing harm mitigation and looking for ways to maximize the positives is the key to longevity in bodybuilding.

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