Tesofensine, also known as NS2330, is technically classified as a presynaptic serotonin–noradrenaline–dopamine reuptake inhibitor. Its pharmacological action leads to the inhibition of the reabsorption of these neurotransmitters by the central nervous system, resulting in reduced feelings of hunger. This compound primarily acts as an appetite suppressant while also influencing fat oxidation and resting energy expenditure. […]Read More
Yohimbine is a potent fat-burning agent that is known for 3 things: Being extremely effective at reducing stubborn fat, improving libido significantly and causing terrible fever-like symptoms in most users. Rauwolscine (alpha-yohimbine) is an isomer of Yohimbine that is slowly gaining popularity as a cleaner, safer yet more effective alternative to its parent compound. It […]Read More
Sobetirome (also known as GC-1) is a Thyroid Receptor Beta-Specific Agonist drug that was developed as a potential alternative to T3 and T4 for the treatment of hypothyroidism. As you know, the thyroid hormones T3 and T4 regulate metabolism and other important physiological processes within the body, so being thyroid deficient is not only incredibly […]Read More
Adipotide (Prohibitin-targeting Peptide 1) is a peptide that was originally developed for the treatment of cancer. However, animal studies found that it could destroy fat cells and cause fat loss. Unfortunately, this drug can be very dangerous if misused, hence its infamous reputation in bodybuilding circles. What does Adipotide do? In a nutshell, Adipotide targets […]Read More
In the world of fitness and nutrition, the term “thermogenic effect” is often associated with fat burners and intense workouts. However, there’s a silent hero in the nutrition realm that plays a pivotal role in this process – protein. Beyond its well-known muscle-building capabilities, protein possesses a hidden thermogenic effect that can significantly impact your […]Read More
Something that we rarely discuss in the bodybuilding community is the impact AAS use has on thyroid function. Is it positive? Is it detrimental? In this article, I will be looking at some of the data regarding the interaction between AAS and endogenous thyroid hormones, and explain why using low doses of exogenous thyroid hormones […]Read More
5-Amino-1MQ is a short-chain peptide that has shown promising results in the treatment of obesity. It is slowly growing in popularity as an excellent oral fat-burner that can reduce body fat significantly without causing serious side-effects. What does 5-AMINO-1MQ do? 5-Amino-1MQ is a membrane-permeable peptide that works by inhibiting NNMT (Nicotinamide N-methyltransferase) and increasing NAD+. […]Read More
Intermittent fasting (IF) is a popular dietary strategy that involves alternating periods of eating and fasting. Some people swear by it as a way to lose fat, improve health, and simplify their lifestyle. But is it good for bodybuilding? Can you build muscle and strength while fasting for hours or even days? In this article, […]Read More
In order to achieve and maintain a lower bodyweight, be it for aesthetic or health-related reasons, people often try various methods, including the use of medications that, although initially designed to help with type-2 diabetes, also aid in weight loss. Two very important options in this class are Mounjaro (tirzepatide) and Ozempic (semaglutide). This article […]Read More
T3 (triiodothyronine) is a naturally-occurring thyroid hormone that regulates metabolism, digestion, cognition, immunity and even sexual function to a small extent. This is a hormone that we all have and need in order to function optimally, but it can also be used exogenously to replace endogenous T3 levels in people with hypothyroidism, or as a […]Read More
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